Limitations of using feline coronavirus spike protein gene mutations to diagnose feline infectious peritonitis
نویسندگان
چکیده
منابع مشابه
Limitations of using feline coronavirus spike protein gene mutations to diagnose feline infectious peritonitis
Feline infectious peritonitis (FIP) is a fatal disease of cats, and a sequela of systemic feline coronavirus (FCoV) infection. Mutations in the viral spike (S) gene have been associated with FCoVs found in tissues from cats with FIP, but not FCoVs found in faeces from healthy cats, and are implicated in monocyte/macrophage tropism and systemic spread. This study was designed to determine whethe...
متن کاملComparison of different tests to diagnose feline infectious peritonitis.
Clinical data from 488 cats (1979-2000) with histopathologically confirmed feline infectious peritonitis (FIP) and 620 comparable controls were evaluated retrospectively to assess the value of several diagnostic tests frequently used in the evaluation of cats with suspected FIP. Diagnostic utility of serum albumin to globulin ratio for the diagnosis of FIP was greater than of the utility of ser...
متن کاملFeline infectious peritonitis.
The article discusses feline infectious peritonitis (FIP), an important disease frequently seen in veterinary practice. FIP causes many problems to the veterinarian as it can be difficult to definitively diagnose the disease, as there is no effective treatment, and as prophylactic interventions are not very successful. Although intense research has created a lot of new knowledge about this dise...
متن کاملUnderstanding Feline Infectious Peritonitis
Dr. Niels C. Pedersen is Director of the Veterinary Genetics Laboratory and Director of the Center for Companion Animal Health at the University of California at Davis. Dr. Pedersen is an international authority on infectious diseases and immunological disorders in small animals and in comparative genetics. His current areas of research focus on infectious diseases of cats and dogs in shelter a...
متن کاملAcquisition of macrophage tropism during the pathogenesis of feline infectious peritonitis is determined by mutations in the feline coronavirus spike protein.
In feline coronavirus (FCoV) pathogenesis, the ability to infect macrophages is an essential virulence factor. Whereas the low-virulence feline enteric coronavirus (FECV) isolates primarily replicate in the epithelial cells of the enteric tract, highly virulent feline infectious peritonitis virus (FIPV) isolates have acquired the ability to replicate efficiently in macrophages, which allows rap...
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ژورنال
عنوان ژورنال: Veterinary Research
سال: 2017
ISSN: 1297-9716
DOI: 10.1186/s13567-017-0467-9